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Tissue engineering of cartilage, tendon and bone

Hengyun SUN, Wei LIU, Guangdong ZHOU, Wenjie ZHANG, Lei CUI, Yilin CAO

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 61-69 doi: 10.1007/s11684-011-0122-1

Abstract:

Tissue engineering aims to produce a functional tissue replacement to repair defects.In our laboratory, we focus on construction of cartilage, tendon and bone.in the engineering of these three tissues, particularly focusing on tissue regeneration and defect repairIn cartilage engineering, articular cartilage was reconstructed and defects were repaired in animal modelsMore sophisticated tissues, such as cartilage in the ear and trachea, were reconstructed both in

Keywords： Tissue engineering     cartilage     bone     tendon     recent advances    

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iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 97-109 doi: 10.1007/s11684-016-0496-1

Abstract: reducing dietary loading directly influences the development and metabolic activity of mandibular condylar cartilagetartrate-resistant acid phosphatase staining indicated the altered histological structure of condylar cartilage

Keywords： condylar cartilage     mechanical loading     proteomic analysis     iTRAQ     bioinformatics analysis    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract: The timing of bile duct injury repair remains controversial.A recent review conducted in France reported 39% complications and 64% failure after immediate repairin 194 patients compared with 14% complications and 8% failure after late repair in 133 patients.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 164-169 doi: 10.1007/s11465-008-0035-0

Abstract: adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair
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Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Engineering 2017, Volume 3, Issue 1,   Pages 28-35 doi: 10.1016/J.ENG.2017.01.010

Abstract:

Given the limited spontaneous repair that follows cartilage injury, demand is growing for tissue engineeringapproaches for cartilage regeneration.One is in orthopedic surgery, in which the engineered cartilage is usually used to repair cartilage defectsrepair cartilage defects or loss in an auricle, trachea, nose, larynx, or eyelid.by the engineered cartilage for the other application.

Keywords： Cartilage tissue engineering     Preclinical immunocompetent animal     investigation     Clinical translation     Orthopedic    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 338-345 doi: 10.1007/s11709-017-0411-0

Abstract: The fast-track repair of deteriorated concrete pavement requires materials that can be placed, cured,Based on the laboratory results, the CSA cement was selected as the partial-depth rapid repair materialThe data collected during and after the repair show that the CSA cement concrete had good short-termand long-term performances and, therefore, was suitable for the rapid repair of concrete pavement.

Keywords： Sulfoaluminate (CSA) cement     Type III cement     coefficient of thermal expansion (CTE)     shrinkage     rapid repair    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 262-272 doi: 10.1007/s11684-019-0717-5

Abstract: Repair, on the other hand, allows restoring the function of an existing but failing organ.The recognition that human lungs can both repair and regenerate is quite novel, the concept has not beenWe present evidence that the human adult lung does repair and regenerate and introduce different waysVarious types of lung stem cells are capable of proliferating and differentiating upon injury driving the repair

Keywords： FGF     human lung     repair     regeneration     stem cells    

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Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 261-269 doi: 10.1007/s11709-017-0394-x

Abstract: mechanical properties and durability characteristics on Engineered Cementitious Composites (ECC) as repairThis study focused on the evaluation of the most factors influencing compatibility between the repairThis lower Young’s modulus is desirable for repair concrete, because it prevents the stresses induced

Keywords： natural pozzolan     engineered cementitious composites     mechanical strengths     elastic modulus     capillary absorption     drying shrinkage    

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Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 147-168 doi: 10.1007/s11709-019-0587-6

Abstract: The second objective is to study the effectiveness of polyethylene repair patches which are used to mendAdditionally, due to the application of pipe joints, and repair patches local stresses superimposed onThe pipe is assumed to be made of PE80 resin and its jointing socket, and the repair patch is PE100 material

Keywords： Ansys software     polyethylene     buried pipelines     polyethylene joints     polyethylene patches     peak von Mises stress     soil-pipe interaction     temperature variation    

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis

Keywords： MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

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Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 463-468 doi: 10.1007/s11684-010-0050-5

Abstract: recurrence rate in the Bassini group was 8.9% (24/269), significantly higher than that in the tension-free repairThe average hospital stay in the Bassini group was longer than that in the tension-free repair group

Keywords： hernioplasty     Bassini repair     tension-free repair     complication    

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Farmers Reap Right to Repair Agricultural Equipment

Mitch Leslie

Engineering 2023, Volume 27, Issue 8,   Pages 8-10 doi: 10.1016/j.eng.2023.06.002

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Decellularized extracellular matrix mediates tissue construction and regeneration

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 56-82 doi: 10.1007/s11684-021-0900-3

Abstract: Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D) structural integrity and cellular-function regulation. Containing the crucial traits of the cellular microenvironment, ECM substitutes mediate cell–matrix interactions to prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissue regeneration in vivo. However, these ECMs are often applied generically and have yet to be extensively developed for specific cell types in 3D cultures. Cultured cells also produce rich ECM, particularly stromal cells. Cellular ECM improves 3D culture development in vitro and tissue remodeling during wound healing after implantation into the host as well. Gaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction or organ regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D organoid culture and tissue remodeling for in vivo regeneration. Overall, the decellularization methodologies and tissue/cell-derived ECM as scaffolds or cellular-growth supplements used in cell propagation and differentiation for 3D tissue culture in vitro are discussed. Moreover, current preclinical applications by which ECM components modulate the wound-healing process are reviewed.

Keywords： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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Title Author Date Type Operation

Tissue engineering of cartilage, tendon and bone

Hengyun SUN, Wei LIU, Guangdong ZHOU, Wenjie ZHANG, Lei CUI, Yilin CAO

Journal Article

iTRAQ-based quantitative proteomic analysis on differentially expressed proteins of rat mandibular condylar cartilage

Liting Jiang,Yinyin Xie,Li Wei,Qi Zhou,Ning Li,Xinquan Jiang,Yiming Gao

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Journal Article

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Journal Article

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Journal Article

Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Journal Article

Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Journal Article

Farmers Reap Right to Repair Agricultural Equipment

Mitch Leslie

Journal Article

Decellularized extracellular matrix mediates tissue construction and regeneration

Journal Article